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Korean J. Vet. Serv. 1999; 22(3): 247-255

Published online October 1, 1999

© The Korean Socitety of Veterinary Service

IBDV (SH/92)의 인공감염에 의한 닭 면역장기의 병리조직학적 연구

엄성심;김범석;임채웅;임병무;이호일;정동석;

전라북도 축산진흥연구소 남원지소;전북대학교 생체안정성연구소;전북대학교 생체안정성연구소;전북대학교 생체안정성연구소;전북대학교 생체안정성연구소;전라북도 축산진흥연구소 남원지소;

Histopathological changes in lymphoid organs of chickens inoculated with IBDV (SBV92)

엄성심;김범석;임채웅;임병무;이호일;정동석;

Correspondence to : 전라북도 축산진흥연구소 남원지소

Abstract

Sequential morphologic changes in the lymphoid organs were examined after ocular and cloacal inoculation in 3weekold chicks with a highly virulent strain (SH/92) of infectious bursal disease virus (IBDV). The infected chickens were sacrificed at 6, 12, 24, 48, 72, and 96 hrs post inoculation (Pl), and thymus, harderian gland, ceacal tonsil, and spleen were observed. Histologically, the significant lesions were characterized by lymphocyte depletion and the earliest detectable changes were evident at 12 hrs Pl. In thymic cortex, lymphoid depletion with apoptosis and prominent "tingible body macrophages" were observed. As the infection advanced, the lesions showed more severe changes. Dying cells were characterized either by capping of nuclear chromatin (apoptosis) or by cytoplasmic swelling (necrosis). In situ staining for apoptosis, some lymphoid cells revealed typical positive reaction, even the stainability was variable depend on every lymphoid organs. These results suggest that IBBV (SH/92) cause severe damage both primary and secondary lymphoid organs, and both T and B lymphocytes. Also the lymphoid depletion of these organs is caused by necrosis and apoptosis induced by IBDV.d by IBDV.

Keywords IBDV (SH/92),Chicken,Lymphocyte depletion,Apoptosis,Necrosis,

Article

Research Article

Korean J. Vet. Serv. 1999; 22(3): 247-255

Published online October 1, 1999

Copyright © The Korean Socitety of Veterinary Service.

IBDV (SH/92)의 인공감염에 의한 닭 면역장기의 병리조직학적 연구

엄성심;김범석;임채웅;임병무;이호일;정동석;

전라북도 축산진흥연구소 남원지소;전북대학교 생체안정성연구소;전북대학교 생체안정성연구소;전북대학교 생체안정성연구소;전북대학교 생체안정성연구소;전라북도 축산진흥연구소 남원지소;

Histopathological changes in lymphoid organs of chickens inoculated with IBDV (SBV92)

엄성심;김범석;임채웅;임병무;이호일;정동석;

Correspondence to:전라북도 축산진흥연구소 남원지소

Abstract

Sequential morphologic changes in the lymphoid organs were examined after ocular and cloacal inoculation in 3weekold chicks with a highly virulent strain (SH/92) of infectious bursal disease virus (IBDV). The infected chickens were sacrificed at 6, 12, 24, 48, 72, and 96 hrs post inoculation (Pl), and thymus, harderian gland, ceacal tonsil, and spleen were observed. Histologically, the significant lesions were characterized by lymphocyte depletion and the earliest detectable changes were evident at 12 hrs Pl. In thymic cortex, lymphoid depletion with apoptosis and prominent "tingible body macrophages" were observed. As the infection advanced, the lesions showed more severe changes. Dying cells were characterized either by capping of nuclear chromatin (apoptosis) or by cytoplasmic swelling (necrosis). In situ staining for apoptosis, some lymphoid cells revealed typical positive reaction, even the stainability was variable depend on every lymphoid organs. These results suggest that IBBV (SH/92) cause severe damage both primary and secondary lymphoid organs, and both T and B lymphocytes. Also the lymphoid depletion of these organs is caused by necrosis and apoptosis induced by IBDV.d by IBDV.

Keywords: IBDV (SH/92),Chicken,Lymphocyte depletion,Apoptosis,Necrosis,

KJVS
Dec 30, 2024 Vol.47 No.4, pp. 193~317

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Korean Journal of
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